作者
Luigino Calzetta, Beatrice Ludovica Ritondo, Patrizia de Marco, Mario Cazzola, Paola Rogliani
发表日期
2021/1/2
来源
Expert Review of Respiratory Medicine
卷号
15
期号
1
页码范围
143-152
出版商
Taylor & Francis
简介
Objectives
In some studies comparing triple with dual combination therapies in COPD there might be a possible effect of inhaler bias resulting from different inhaler devices being used in comparator arms. The aim of this study was a quantitative synthesis by considering the studies that directly compared triple ICS/LABA/LAMA vs. either dual LABA/LAMA or ICS/LABA therapies administered at fixed-dose combination (FDC) via the same inhaler device.
Methods
A network meta-analysis was performed to assess the efficacy/safety impact of triple ICS/LABA/LAMA FDC compared with dual LABA/LAMA and ICS/LBA FDCs administered via the same inhaler device in COPD patients. The treatment ranking was reported via the surface under the cumulative ranking curve analysis (SUCRA).
Results
Data obtained from 21,909 COPD patients were extracted from the ETHOS, KRONOS, IMPACT, and TRILOGY studies, the only …
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L Calzetta, BL Ritondo, P de Marco, M Cazzola… - Expert Review of Respiratory Medicine, 2021