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The influence of formulation variables, i.e., a hydrophilic polymer (Methocel^® E15) and a film-forming polymer (Eudragit^® RL 100 and Eudragit^® RS 100), on the physicochemical and functional properties of a transdermal film formulation was assessed. Several terpenes were initially evaluated for their drug permeation enhancement effects on the transdermal film formulations. d-Limonene was found to be the most efficient permeation enhancer among the tested terpenes. Transdermal film formulations containing granisetron (GRN) as a model drug, d-limonene as a permeation enhancer, and different ratios of a hydrophilic polymer (Methocel^® E15) and a film-forming polymer (Eudragit^® RL 100 or Eudragit^® RS 100) were prepared. The prepared films were evaluated for their physicochemical properties such as weight variation, thickness, tensile strength, folding endurance, elongation (%), flatness …