作者
Sara Gianella, Christy M Anderson, Milenka V Vargas, Douglas D Richman, Susan J Little, Sheldon R Morris, Davey M Smith
发表日期
2013/3/15
期刊
The Journal of infectious diseases
卷号
207
期号
6
页码范围
898-902
出版商
Oxford University Press
简介
Over three-fourths of human immunodeficiency virus (HIV)–infected men who have sex with men (MSM) have at least one herpesvirus detected in their semen, and cytomegalovirus (CMV) is the most prevalent. The presence of CMV is associated with higher T-cell immune activation and with HIV disease progression in treated and untreated individuals. In this study of 113 antiretroviral (ART)–naive HIV-infected MSM, we found that CMV replication in blood and semen was associated with higher levels of HIV DNA in peripheral blood mononuclear cells. These observations suggest that interventions aimed to reduce CMV replication and, thus, systemic immune activation could decrease the size of the latent HIV reservoir.
学术搜索中的文章
S Gianella, CM Anderson, MV Vargas, DD Richman… - The Journal of infectious diseases, 2013