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Exercise improves weight status and metabolism. Irisin, a novel myokine, may be involved in the regulation of metabolic function. The effect of an exercise and dietary lifestyle intervention for 1‐year on irisin, adipokines (leptin, adiponectin, resistin) and inflammatory markers (C‐reactive protein (CRP), soluble tumor necrosis factor receptor II (sTNFR‐II) was evaluated, and predictors of irisin levels were characterized in obese children.

Parameters were assessed at baseline and at follow‐up for 65 obese children who completed the program (7–18 years, 54%boys). Their relation to weight status and metabolic risk was analyzed.

Anthropometric and metabolic parameters improved after completion of the program. Circulating irisin levels at baseline were 111.0 ± 8.0 ng ml⁻¹ and increased after the intervention by 12% [6%, 17%], P = 0.00003. There was no evidence for differences in irisin …