作者
Leslie Skeith, Marc Carrier, Risto Kaaja, Ida Martinelli, David Petroff, Ekkehard Schleußner, Carl A Laskin, Marc A Rodger
发表日期
2016/3/31
来源
Blood, The Journal of the American Society of Hematology
卷号
127
期号
13
页码范围
1650-1655
出版商
American Society of Hematology
简介
We performed a meta-analysis of randomized controlled trials comparing low-molecular-weight heparin (LMWH) vs no LMWH in women with inherited thrombophilia and prior late (≥10 weeks) or recurrent early (<10 weeks) pregnancy loss. Eight trials and 483 patients met our inclusion criteria. There was no significant difference in livebirth rates with the use of LMWH compared with no LMWH (relative risk, 0.81; 95% confidence interval, 0.55-1.19; P = .28), suggesting no benefit of LMWH in preventing recurrent pregnancy loss in women with inherited thrombophilia.
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L Skeith, M Carrier, R Kaaja, I Martinelli, D Petroff… - Blood, The Journal of the American Society of …, 2016