作者
Michael N Kammer, Dhairya A Lakhani, Aneri B Balar, Sanja L Antic, Amanda K Kussrow, Rebekah L Webster, Shayan Mahapatra, Udaykamal Barad, Chirayu Shah, Thomas Atwater, Brenda Diergaarde, Jun Qian, Alexander Kaizer, Melissa New, Erin Hirsch, William J Feser, Jolene Strong, Matthew Rioth, York E Miller, Yoganand Balagurunathan, Dianna J Rowe, Sherif Helmey, Sheau-Chiann Chen, Joseph Bauza, Stephen A Deppen, Kim Sandler, Fabien Maldonado, Avrum Spira, Ehab Billatos, Matthew B Schabath, Robert J Gillies, David O Wilson, Ronald C Walker, Bennett Landman, Heidi Chen, Eric L Grogan, Anna E Barón, Darryl J Bornhop, Pierre P Massion
发表日期
2021/12/1
期刊
American journal of respiratory and critical care medicine
卷号
204
期号
11
页码范围
1306-1316
出版商
American Thoracic Society
简介
Rationale: Patients with indeterminate pulmonary nodules (IPNs) at risk of cancer undergo high rates of invasive, costly, and morbid procedures.
Objectives: To train and externally validate a risk prediction model that combined clinical, blood, and imaging biomarkers to improve the noninvasive management of IPNs.
Methods: In this prospectively collected, retrospective blinded evaluation study, probability of cancer was calculated for 456 patient nodules using the Mayo Clinic model, and patients were categorized into low-, intermediate-, and high-risk groups. A combined biomarker model (CBM) including clinical variables, serum high sensitivity CYFRA 21-1 level, and a radiomic signature was trained in cohort 1 (n = 170) and validated in cohorts 2–4 (total n = 286). All patients were pooled to recalibrate the model for clinical implementation. The clinical utility of the CBM compared with current clinical care was …
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MN Kammer, DA Lakhani, AB Balar, SL Antic… - American journal of respiratory and critical care …, 2021