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Methods: Data from the cross-sectional, 2005–2006 US National Health and Nutritional Examination Survey (NHANES) were analyzed, adjusting for the complex sampling design. Adults aged 30 to 74 years with 4+ days of accelerometer data and self-reported sleep duration were included in analyses (N= 3,238). Adults with sleep disorders and pregnant/lactating women were excluded. Cardiovascular (Framingham Risk Score and homocysteine levels), adiposity (body mass index and waist circumference), inflammatory (C-reactive protein), insulin resistance (HOMA-IR and HOMA-B), and hyperinsulinemia biomarkers were examined. Isotemporal substitution methods were used to estimate replacement effects for accelerometer-derived activity (MVPA:> 1951 cpm; light-intensity: 100–1951 cpm; sedentary:< 100 cpm) and reported sleep time (duration, sleep onset latency) variables on selected biomarkers.

Results …