作者
Huanzi Zhong, John Penders, Zhun Shi, Huahui Ren, Kaiye Cai, Chao Fang, Qiuxia Ding, Carel Thijs, Ellen E Blaak, Coen DA Stehouwer, Xun Xu, Huanming Yang, Jian Wang, Jun Wang, Daisy MAE Jonkers, Ad AM Masclee, Susanne Brix, Junhua Li, Ilja CW Arts, Karsten Kristiansen
发表日期
2019/12
期刊
Microbiome
卷号
7
页码范围
1-14
出版商
BioMed Central
简介
Background
The gut microbiota evolves from birth and is in early life influenced by events such as birth mode, type of infant feeding, and maternal and infant antibiotics use. However, we still have a gap in our understanding of gut microbiota development in older children, and to what extent early events and pre-school lifestyle modulate the composition of the gut microbiota, and how this impinges on whole body metabolic regulation in school-age children.
Results
Taking advantage of the KOALA Birth Cohort Study, a long-term prospective birth cohort in the Netherlands with extensive collection of high-quality host metadata, we applied shotgun metagenomics sequencing and systematically investigated the gut microbiota of children at 6–9 years of age. We demonstrated an overall adult-like gut microbiota in the 281 Dutch school-age children and …
学术搜索中的文章
H Zhong, J Penders, Z Shi, H Ren, K Cai, C Fang… - Microbiome, 2019