作者
Gerda Kildisiute, Waleed M Kholosy, Matthew D Young, Kenny Roberts, Rasa Elmentaite, Sander R van Hooff, Clarissa N Pacyna, Eleonora Khabirova, Alice Piapi, Christine Thevanesan, Eva Bugallo-Blanco, Christina Burke, Lira Mamanova, Kaylee M Keller, Karin PS Langenberg-Ververgaert, Philip Lijnzaad, Thanasis Margaritis, Frank CP Holstege, Michelle L Tas, Marc HWA Wijnen, Max M van Noesel, Ignacio Del Valle, Giuseppe Barone, Reinier van der Linden, Catriona Duncan, John Anderson, John C Achermann, Muzlifah Haniffa, Sarah A Teichmann, Dyanne Rampling, Neil J Sebire, Xiaoling He, Ronald R de Krijger, Roger A Barker, Kerstin B Meyer, Omer Bayraktar, Karin Straathof, Jan J Molenaar, Sam Behjati
发表日期
2021/2/5
期刊
Science advances
卷号
7
期号
6
页码范围
eabd3311
出版商
American Association for the Advancement of Science
简介
Neuroblastoma is a childhood cancer that resembles developmental stages of the neural crest. It is not established what developmental processes neuroblastoma cancer cells represent. Here, we sought to reveal the phenotype of neuroblastoma cancer cells by comparing cancer (n = 19,723) with normal fetal adrenal single-cell transcriptomes (n = 57,972). Our principal finding was that the neuroblastoma cancer cell resembled fetal sympathoblasts, but no other fetal adrenal cell type. The sympathoblastic state was a universal feature of neuroblastoma cells, transcending cell cluster diversity, individual patients, and clinical phenotypes. We substantiated our findings in 650 neuroblastoma bulk transcriptomes and by integrating canonical features of the neuroblastoma genome with transcriptional signals. Overall, our observations indicate that a pan-neuroblastoma cancer cell state exists, which may be attractive for …
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G Kildisiute, WM Kholosy, MD Young, K Roberts… - Science advances, 2021