作者
Graziella Cefalo, Maura Massimino, Antonio Ruggiero, Giuseppe Barone, Vita Ridola, Filippo Spreafico, Paolo Potepan, Massimo E Abate, Maurizio Mascarin, Maria Luisa Garrè, Giorgio Perilongo, Enrico Madon, Cesare Colosimo, Riccardo Riccardi
发表日期
2014/5/1
期刊
Neuro-oncology
卷号
16
期号
5
页码范围
748-753
出版商
Oxford University Press
简介
Background
The aim of this study was to assess the objective response rate (ORR) of children and young adults with recurrent medulloblastoma/primitive neuroectodermal tumor (MB/PNET) treated with temozolomide (TMZ). The secondary purpose was to analyze the toxicity profile of TMZ when administered orally for 5 days in 3 divided daily doses every 28 days.
Methods
Forty-two patients with recurrent MB/PNET, aged 21 years and younger, were recruited. Patients were treated with oral TMZ. Starting doses ranged from 120 to 200 mg/m2/day based on previous treatments. A craniospinal MRI was performed prior to the first cycle of TMZ and following every 2 cycles of treatment.
Results
Median age was 10 years (range, 2–21 years). Forty of 42 patients were assessed for response and toxicity. The objective response rate was 42.5%: 6 patients achieved …
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G Cefalo, M Massimino, A Ruggiero, G Barone… - Neuro-oncology, 2014