作者
Kim S Thomas, Anthony D Ormerod, Fiona E Craig, Nicola Greenlaw, John Norrie, Eleanor Mitchell, James M Mason, Graham A Johnston, Shyamal Wahie, Hywel C Williams, Julie Barnes, Brian Barnes, Fiona Craig, Katharine Foster, Ellie Harrison, Sally Kucyj, Alan Maplethorpe, James Mason, Anthony Ormerod, Aisha Shafayat, Daniel Simpkins, Kim Thomas, Diane Whitham, Hywel Williams, Linda Lawson, Alex Anstey, Catherine Watkins, Sarah Mitchell, Richard Goodwin, Cilla Benge, Gosia Skibinska, N Ariffin, Janice Armitt, Nhlanhla Mguni, Maxwell Masuku, Kerry Goodsell, Linda Johnson, John Ingram, Girish Patel, Mabs Chowdhury, Richard Motley, Anne Thomas, Colin Long, Anew Morris, Vincent Piguet, Manju Kalavala, Ru Katugampla, Catherine Blasdale, Stephanie Lateo, Neil Rajan, Anne Thomson, Sivakumar Natarajan, Therese Sripathy, Maneesha Vatve, Vrinda Bajaj, Keith Freeman, Mary Carr, Adam Ferguson, Katherine Riches, Susannah Baron, Claire Fuller, Anthea Potter, Laura Brockway, Ashley Cooper, Susan Thompson, Emilia Duarte-Williamson, Catherine Smith, Gemma Minifie, Naomi Hare, Kate Thornberry, Shika Gupta, Sinead Langan, Alison Layton, Angela Wray, Benjamin Walker, Gayle Law, Elizabeth Marshall, Shernaz Walton, Katherine Ashton, Angela Oswald, Deborah Graham, Peter Jones, Vanessa Smith, Debbie Shipley, Claire Duggan, Sarah Jones, Carol Thomas, Sally-Ann Rolls, Emma Veysey, Simon Meggitt, Nick Levell, Kevin Lee, Pariyawan Rakvit, George Millington, Karen Banks-Dunnell, Natasha Chetty, Clive Grattan, Syed Shah, Donna Butcher, Marinela Nik, Kathleen Gilbanks, Neil Cox, John English, Ruth Murphy, William Perkins, Sheelagh Littlewood, Jan Bong, Moona Malik, Jonathan Batchelor, Catriona Wootton, Sue Davies-Jones, Joanne Llewellyn, Suzanne Cheng, Maulina Sharma, Janet Angus, Sandeep Varma, Stuart Cohen, Graham Ogg, Susan Burge, Vanessa Venning, Susan Cooper, Tess McPherson, Lisa Matter, Christopher Bower, Robert James, Shireen Velangi, Weronika Szczecinska, Tinomuda Shumba, Jane Ravenscroft, Azaharry Yaakub, Hong Trinh, Anna Chapman, Natalie Miller, Yana Estfan, Gwendoline Reeves, Rachel Wachsmuth, Victoria Lewis, Hazel Bell, Richard Azurdia, Maeve Walsh, Caroline Angit, Kok Ngan, Anea Young, Julie Murgaza, Paula Taylor, Hamish Hunter, Agustin Martin-Clavijo, Renuga Raghavenan, Lucy Evriviades, Helen Lewis
发表日期
2016/11/1
期刊
Journal of the American Academy of Dermatology
卷号
75
期号
5
页码范围
940-949
出版商
Mosby
简介
Background
Pyoderma gangrenosum (PG) is an uncommon dermatosis with a limited evidence base for treatment.
Objective
We sought to estimate the effectiveness of topical therapies in the treatment of patients with PG.
Methods
This was a prospective cohort study of UK secondary care patients with a clinical diagnosis of PG that was suitable for topical treatment (recruited between July 2009 and June 2012). Participants received topical therapy after normal clinical practice (primarily topical corticosteroids [classes I-III] and tacrolimus 0.03% or 0.1%). The primary outcome was speed of healing at 6 weeks. Secondary outcomes included the following: proportion healed by 6 months; time to healing; global assessment; inflammation; pain; quality of life; treatment failure; and recurrence.
Results
Sixty-six patients (22-85 years of age) were enrolled. Clobetasol propionate 0.05% was the most commonly prescribed therapy …
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KS Thomas, AD Ormerod, FE Craig, N Greenlaw… - Journal of the American Academy of Dermatology, 2016