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Objective:

Alzheimer’s disease is the most common type of neurodegenerative disorder. It has been suggested that oxidative stress can be one of the pathological mechanisms of this disease. Carnosic acid (CA) is an effective antioxidant substance and recent studies have shown that its electrophilic compounds play a role in reversing oxidative stress. Thus we tried to find out whether CA administration protects hippocampal neurons, preventing neurodegeneration in rats.

Materials and Methods:

Animals were divided into four groups: Sham-operated (sham), CA-pretreated sham-operated (sham+ CA), untreated lesion (lesion) and CA-pretreated lesion (lesion+ CA). Animals in all groups received vehicle or vehicle plus CA (CA: 10mg/kg) intra-peritoneally one hour before surgery, again the same solution injected 3-4 hours after surgery (CA: 3 mg/kg) and repeated each afternoon for 12 days. A lesion was made by …