作者
Zane A Brown, Anna Wald, R Ashley Morrow, Stacy Selke, Judith Zeh, Lawrence Corey
发表日期
2003/1/8
期刊
Jama
卷号
289
期号
2
页码范围
203-209
出版商
American Medical Association
简介
Context
Neonatal herpes most commonly results from fetal exposure to infected maternal genital secretions at the time of delivery. The risk of transmission from mother to infant as it relates to maternal herpes simplex virus (HSV) serologic status and exposure to HSV in the maternal genital tract at the time of labor has not been quantified. Furthermore, no data exist on whether cesarean delivery, the standard of care for women with genital herpes lesions at the time of delivery, reduces HSV transmission.
Objective
To determine the effects of viral shedding, maternal HSV serologic status, and delivery route on the risk of transmission of HSV from mother to infant.
Design
Prospective cohort of pregnant women enrolled between January 1982 and December 1999.
Settings
A university medical center, a US Army medical center, and 5 community hospitals in Washington State.
Patients
A total of 58 362 pregnant women, of …
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ZA Brown, A Wald, RA Morrow, S Selke, J Zeh, L Corey - Jama, 2003