作者
Namrata S Patil, Luisella Righi, Hartmut Koeppen, Wei Zou, Stefania Izzo, Federica Grosso, Roberta Libener, Marco Loiacono, Valentina Monica, Consuelo Buttigliero, Silvia Novello, Priti S Hegde, Mauro Papotti, Marcin Kowanetz, Giorgio V Scagliotti
发表日期
2018/1/1
期刊
Journal of Thoracic Oncology
卷号
13
期号
1
页码范围
124-133
出版商
Elsevier
简介
Introduction
Malignant pleural mesothelioma (MPM) is a rare, highly aggressive, and relatively chemoresistant and radioresistant malignancy with limited therapeutic options. Our objective was to investigate the prevalence of programmed death ligand 1 (PD-L1) and the characteristics of the immune environment in this disease.
Methods
A total of 99 archival tumors from advanced-stage MPM were immunohistochemically tested in parallel for PD-L1 in two different laboratories, and 87 of them were profiled for immune gene expression by NanoString analysis for 800 genes. A prior study on the same samples indicated a low mutational load with a complex mutational landscape of genetic variations more frequently associated with the p53/DNA repair and phosphoinisitide-3-kinase pathways.
Results
PD-L1 expression was found in 16% of the MPM tumor samples, either in the tumor cells or the infiltrating immune cells …
学术搜索中的文章
NS Patil, L Righi, H Koeppen, W Zou, S Izzo, F Grosso… - Journal of Thoracic Oncology, 2018