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To conduct a fully independent and external validation of a research study based on one electronic health record database, using a different electronic database sampling the same population.

Using the Clinical Practice Research Datalink (CPRD), we replicated a published investigation into the effects of statins in patients with ischaemic heart disease (IHD) by a different research team using QResearch. We replicated the original methods and analysed all-cause mortality using: (1) a cohort analysis and (2) a case-control analysis nested within the full cohort.

Electronic health record databases containing longitudinal patient consultation data from large numbers of general practices distributed throughout the UK.

CPRD data for 34 925 patients with IHD from 224 general practices, compared to previously published results from QResearch for 13 029 patients from 89 general …