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Nanotechnology emerged as a powerful approach in recent years as it shows extraordinary possible applications in preventing and treating wound infections as compared to conventional methods. In this view, the physiochemical properties of nanomaterials empower research workers to explore their research on wound management applications. Moreover, multiple research groups have developed numerous nanomaterials and investigated their advanced potential efficiency in wound healing applications. This chapter focuses on the importance of nanotechnological-based approaches for wound healing applications.