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Results:

Eight trials were identified involving 439 patients, 228 of whom received esmolol while 211 received opioids. A random-effects meta-analysis showed that in comparison with opioids, esmolol led to a 69% reduction in the incidence of PONV (odds ratio 0.31, 95% confidence interval [CI] 0.13–0.74, P= 0.008, I 2= 44.1%). An increase in the volatile anesthetic requirement was evident in the esmolol group compared with opioid (MD+ 0.67% desflurane equivalent, 95% CI 0.27–1.08, P= 0.001, I 2= 23.5%). There was no statistically significant difference between the esmolol and opioid groups in relation to PACU discharge time, early postoperative pain scores, opioid requirement, and cumulative opioid consumption. Significant heterogeneity was noted between studies. No significant adverse effects were noted.

Conclusion:

Compared with opioids, perioperative esmolol may reduce the incidence of postoperative …