作者
Quentin Leyrolle, Renata Cserjesi, Maria DGH Mulders, Giorgia Zamariola, Sophie Hiel, Marco A Gianfrancesco, Daphné Portheault, Camille Amadieu, Laure B Bindels, Sophie Leclercq, Julie Rodriguez, Audrey M Neyrinck, Patrice D Cani, Nicolas Lanthier, Pierre Trefois, Jérome Bindelle, Nicolas Paquot, Miriam Cnop, Jean-Paul Thissen, Olivier Klein, Olivier Luminet, Nathalie M Delzenne
发表日期
2021/5/1
期刊
Brain, behavior, and immunity
卷号
94
页码范围
289-298
出版商
Academic Press
简介
Background and aims
Metabolic and behavioural diseases, which are often related to obesity, have been associated to alterations of the gut microbiota considered as an interesting therapeutic target. We have analyzed in a cohort of obese patients treated with prebiotic inulin versus placebo the potential link between gut microbiota changes occurring upon intervention and their effect on psychological parameters (mood and cognition).
Methods
A randomized, single-blinded, multicentric, placebo-controlled trial was conducted in 106 obese patients assigned to two groups: prebiotic versus placebo, who received respectively 16 g/d of native inulin or maltodextrin combined with dietary advice to consume inulin-rich or -poor vegetables for 3 months as well as to restrict caloric intake. Anthropometric measurements, food intake, psychological questionnaires, serum measures, and fecal microbiome sequencing were …
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Q Leyrolle, R Cserjesi, MDGH Mulders, G Zamariola… - Brain, behavior, and immunity, 2021