作者
Wonhyo Seo, Yanhang Gao, Yong He, Jing Sun, Hongqin Xu, Dechun Feng, Seol Hee Park, Young-Eun Cho, Adrien Guillot, Tianyi Ren, Ruihong Wu, Jingyun Wang, Seung-Jin Kim, Seonghwan Hwang, Suthat Liangpunsakul, Yingzi Yang, Junqi Niu, Bin Gao
发表日期
2019/11/1
期刊
Journal of hepatology
卷号
71
期号
5
页码范围
1000-1011
出版商
Elsevier
简介
Background & Aims
Excessive alcohol consumption is one of the major causes of hepatocellular carcinoma (HCC). Approximately 30–40% of the Asian population are deficient for aldehyde dehydrogenase 2 (ALDH2), a key enzyme that detoxifies the ethanol metabolite acetaldehyde. However, how ALDH2 deficiency affects alcohol-related HCC remains unclear.
Methods
ALDH2 polymorphisms were studied in 646 patients with viral hepatitis B (HBV) infection, who did or did not drink alcohol. A new model of HCC induced by chronic carbon tetrachloride (CCl4) and alcohol administration was developed and studied in 3 lines of Aldh2-deficient mice: including Aldh2 global knockout (KO) mice, Aldh2*1/*2 knock-in mutant mice, and liver-specific Aldh2 KO mice.
Results
We demonstrated that ALDH2 deficiency was not associated with liver disease progression but was associated with an increased risk of HCC …
学术搜索中的文章
W Seo, Y Gao, Y He, J Sun, H Xu, D Feng, SH Park… - Journal of hepatology, 2019
