作者
Clemens Von Schacky, Peter Angerer, Wolfgang Kothny, Karl Theisen, Harald Mudra
发表日期
1999/4/6
期刊
Annals of internal medicine
卷号
130
期号
7
页码范围
554-562
出版商
American College of Physicians
简介
Background
Epidemiologic studies, studies of mechanisms of action, and many animal studies indicate that dietary intake of ω-3 fatty acids has antiatherosclerotic potential. Few trials in humans have examined this potential.
Objective
To determine the effect of dietary intake of ω-3 fatty acids on the course of coronary artery atherosclerosis in humans.
Design
Randomized, double-blind, placebo-controlled, clinically controlled trial.
Setting
University preventive cardiology unit.
Patients
223 patients with angiographically proven coronary artery disease.
Intervention
Fish oil concentrate (55% eicosapentaenoic and docosahexaenoic acids) or a placebo with a fatty acid composition resembling that of the average European diet, 6 g/d for 3 months and …
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C Von Schacky, P Angerer, W Kothny, K Theisen… - Annals of internal medicine, 1999