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There is growing speculation that peppermint may target the mechanisms central to cardiometabolic pathophysiology, though there has yet to be any randomized interventions, examining the efficacy of peppermint supplementation on cardiometabolic outcomes. This trial aimed to examine the effect of peppermint supplementation on cardiometabolic and other health indices following a 20-day supplementation period.

A randomized, placebo-controlled parallel study design was adopted (NCT05071833). Thirty-six healthy adults were assigned into either peppermint or placebo trial arms, of which they drank 50 μL of either peppermint or peppermint flavored placebo, diluted in 100 mL of water twice per day for 20 days. Participants were blinded to their trial arm assignment, lead investigators and those analyzing the data were blinded until the data were analyzed and those involved in collecting …