作者
Michael C Stallings, Robin P Corley, Briana Dennehey, John K Hewitt, Kenneth S Krauter, Jeffrey M Lessem, Susan K Mikulich-Gilbertson, Soo Hyun Rhee, Andrew Smolen, Susan E Young, Thomas J Crowley
发表日期
2005/9/1
期刊
Archives of general psychiatry
卷号
62
期号
9
页码范围
1042-1051
出版商
American Medical Association
简介
Background
Among adolescents, externalizing problem behavior and substance use disorders are often comorbid. Familial influences, including shared genetic risk factors, may account for part of this comorbidity. Previously we reported 2 chromosomal regions (3q24-3q25 and 9q34) likely to contain genes that influence substance dependence vulnerability (DV) in adolescence.
Objectives
To identify quantitative trait loci (QTLs) that influence externalizing problem behavior in adolescence and to determine whether any identified QTL overlap chromosomal regions that influence DV.
Design
Regression-based QTL mapping procedures designed for selected sibling pair samples.
Setting
Patient probands were drawn from consecutive admissions to residential and outpatient (milieu-type) treatment facilities for substance abuse and deliquency operated by the University of Colorado; most of these patients were referred for …
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