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Oxylipins, including eicosanoids, are highly bioactive molecules endogenously produced from polyunsaturated fatty acids. Oxylipins play a key role in chronic disease progression. It is possible, but unknown, if oxylipin concentrations change with the consumption of functional foods or differ with subject age.

Therefore, in a parallel comparator trial, 20 healthy individuals were recruited into a younger (19–28 years) or older (45–64 years) age group (n = 10/group). Participants ingested one muffin/day containing 30 g of milled flaxseed (6 g alpha-linolenic acid) for 4 weeks. Plasma oxylipins were isolated through solid phase extraction, analyzed with HPLC-MS/MS targeted lipidomics, and quantified with the stable isotope dilution method.

At baseline, the older group exhibited 13 oxylipins ≥ 2-fold the concentration of the younger group. Specifically, pro-inflammatory oxylipins 5 …