作者
Kenji Murata, Takanori Kokubun, Yuri Morishita, Katsuya Onitsuka, Shuhei Fujiwara, Aya Nakajima, Tsutomu Fujino, Kiyomi Takayanagi, Naohiko Kanemura
发表日期
2018/10
期刊
Cartilage
卷号
9
期号
4
页码范围
391-401
出版商
SAGE Publications
简介
Objective
Osteoarthritis (OA) is induced by accumulated mechanical stress to joints; however, little has been reported regarding the cause among detailed mechanical stress on cartilage degeneration. This study investigated the influence of the control of abnormal joint movement induced by anterior cruciate ligament (ACL) injury in the articular cartilage.
Design
The animals were divided into 3 experimental groups: CAJM group (n = 22: controlling abnormal joint movement), ACL-T group (n = 22: ACL transection or knee anterior instability increased), and INTACT group (n = 12: no surgery). After 2 and 4 weeks, the knees were harvested for digital microscopic observation, soft X-ray analysis, histological analysis, and synovial membrane molecular evaluation.
Results
The 4-week OARSI scores showed that cartilage degeneration was significantly inhibited in the CAJM group as compared with the ACL-T group (P < 0 …
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K Murata, T Kokubun, Y Morishita, K Onitsuka… - Cartilage, 2018