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Meropenem and piperacillin are two commonly prescribed antibiotics in critically ill surgical patients. To date, the pharmacokinetics of these antibiotics in the presence of indwelling abdominal surgical drains is poorly defined. This was a prospective pharmacokinetic study of meropenem and piperacillin. Serial plasma, urine and surgical drain fluid samples were collected over one dosing interval of antibiotic treatment in ten patients (meropenem, n=5; piperacillin n=5). Drug concentrations were measured using a validated high-performance liquid chromatography assay. Median (interquartile range) pharmacokinetic parameter estimates for meropenem were as follows: area under concentration–time curve (AUC), 128.7mgh/L (95.3–176.7mgh/L); clearance (CL), 5.7L/h (5.1–10.5L/h); volume of distribution (V_d), 0.41L/kg (0.35–0.56L/kg); AUC ratio (drain:plasma), 0.2 (0.1–0.2); and calculated antibiotic clearance via …