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Aspilia africana (Pers) CD Adams, a plant used for centuries in many African countries to treat diseases such as osteoporosis, malaria, tuberculosis, and diabetes, is of great pharmaceutical interest, yet there is limited scientific literature on its germination and growth. This research paper describes the effects of different commercial soils on the germination, growth, and chlorophyll content of A. africana. The germination parameters assessed included final germination percentage (FGP), mean germination time (MGT), and germination index (GI). Shoot length, leaf number, and fresh and dry weights were some of the parameters used to assess A. africana growth. The FGP was low and did not vary significantly; the MGT was 7~ 10 days; and the GI was significantly higher in PPS soil at 4.61±0.332 days. Aspilia africana plants in HS: PPS soil showed the best overall growth, producing the highest mean leaf number (18.00±1.129), longest mean shoot length (202.43±13.451 mm), and highest mean fresh and dry weights (7.08±1.061 g and 0.629±0.112 g, respectively). The highest chlorophyll content in leaves of A. africana under HS: PPS conditions suggested a higher photosynthetic potential of plants in this soil. The best growth performance of A. africana in the HS: PPS soil could be attributed to a higher amount of certain mineral nutrients such as nitrogen, potassium, and phosphorus in the HS: PPS soil compared to the other soil categories. It is unclear why the FGP of A. africana was low and we recommend an exclusive study to investigate this further.