作者
Xianding Deng, Miguel A Garcia-Knight, Mir M Khalid, Venice Servellita, Candace Wang, Mary Kate Morris, Alicia Sotomayor-González, Dustin R Glasner, Kevin R Reyes, Amelia S Gliwa, Nikitha P Reddy, Claudia Sanchez San Martin, Scot Federman, Jing Cheng, Joanna Balcerek, Jordan Taylor, Jessica A Streithorst, Steve Miller, Bharath Sreekumar, Pei-Yi Chen, Ursula Schulze-Gahmen, Taha Y Taha, Jennifer Hayashi, Camille R Simoneau, G Renuka Kumar, Sarah McMahon, Peter V Lidsky, Yinghong Xiao, Peera Hemarajata, Nicole M Green, Alex Espinosa, Chantha Kath, Monica Haw, John Bell, Jill K Hacker, Carl Hanson, Debra A Wadford, Carlos Anaya, Donna Ferguson, Phillip A Frankino, Haridha Shivram, Liana F Lareau, Stacia K Wyman, Melanie Ott, Raul Andino, Charles Y Chiu
发表日期
2021/4/20
期刊
Cell
出版商
Cell Press
简介
We identified an emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant by viral whole-genome sequencing of 2,172 nasal/nasopharyngeal swab samples from 44 counties in California, a state in the western United States. Named B.1.427/B.1.429 to denote its two lineages, the variant emerged in May 2020 and increased from 0% to >50% of sequenced cases from September 2020 to January 2021, showing 18.6%–24% increased transmissibility relative to wild-type circulating strains. The variant carries three mutations in the spike protein, including an L452R substitution. We found 2-fold increased B.1.427/B.1.429 viral shedding in vivo and increased L452R pseudovirus infection of cell cultures and lung organoids, albeit decreased relative to pseudoviruses carrying the N501Y mutation common to variants B.1.1.7, B.1.351, and P.1. Antibody neutralization assays revealed 4.0- to 6.7-fold …
学术搜索中的文章
X Deng, MA Garcia-Knight, MM Khalid, V Servellita… - Cell, 2021
X Deng, MA Garcia-Knight, MM Khalid, V Servellita… - MedRxiv, 2021