作者
Fatemeh Darvizeh, Samuel Asanad, Khalil Ghasemi Falavarjani, Jessica Wu, Jack J Tian, Francesco Bandello, Fred N Ross-Cisneros, Piero Barboni, Enrico Borrelli, Alfredo A Sadun
发表日期
2020/9
期刊
Eye
卷号
34
期号
9
页码范围
1624-1630
出版商
Nature Publishing Group UK
简介
Background/Objectives
Choroidal thinning has been suggested in Leber’s hereditary optic neuropathy (LHON). No study has been conducted of the choroid in relation to the retinal ganglion cell-inner plexiform layer (RGC-IPL). We sought to measure choroidal thickness in chronic LHON and to correlate thickness changes with the RGC-IPL.
Subjects/Methods
Chronic LHON, 11778 mitochondrial DNA (mtDNA) mutation, patients (26 eyes; mean age: 35.1 ± 16.1 years) were prospectively recruited at Doheny Eye Center, University of California Los Angeles from March 2016 to July 2017. Age-matched healthy controls (27 eyes; mean age: 32.4 ± 11.1 years) were enroled for comparison. Swept-source optical coherence tomography (SS-OCT) imaging was performed in chronic LHON patients and compared with age-matched healthy controls.
Results
The macular choroid was significantly thinner in chronic LHON …
学术搜索中的文章
F Darvizeh, S Asanad, KG Falavarjani, J Wu, JJ Tian… - Eye, 2020