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Although antidepressants can relieve the symptoms of depression in patients with type-2 diabetes mellitus, the effect of vitamin D supplementation as an antidepressant remains unclear. The present study aimed to investigate the impact of intramuscular vitamin D supplement injections on depression and anthropometric indices in patients with type 2 diabetes who had vitamin D deficiency.

In this randomized controlled clinical trial, 50 patients with type 2 diabetes mellitus who had vitamin D deficiency were randomly divided into two groups of 25 participants. The experimental group received 200,000 IU of vitamin D injection at week 0 and week 4 of the study. Anthropometric indices, serum 25-hydroxyvitamin D [25(OH)D] concentrations and Beck depression test were evaluated at the beginning and after 8 weeks.

There were no significant differences in the baseline measures of 25(OH)D …