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The impact of a comprehensive HIV education, housing support, and 12-step recovery program in a day treatment program for homeless persons infected with HIV was studied. Participants' knowledge of HIV and substance abuse risk factors was assessed for a group of new clients and for a group of clients enrolled for 3 months using an author-developed questionnaire. Continuation of high-risk sexual and substance use behaviors was assessed using the approach. Success in maintaining housing and 12-step recovery was assessed using a retrospective chart review on a separate group of past participants. Statistically significant positive changes in participants' knowledge of HIV and substance use and a decrease in self-reported high-risk behaviors were found. The retrospective chart review also indicated positive changes in housing stability and substance abuse recovery …