作者
Marco Fiore, Carla Petrella, Giovanna Coriale, Pamela Rosso, Elena Fico, Massimo Ralli, Antonio Greco, Marco De Vincentiis, Antonio Minni, Antonella Polimeni, Mario Vitali, Marisa P Messina, Giampiero Ferraguti, Francesca Tarani, Simone de Persis, Mauro Ceccanti, Luigi Tarani
发表日期
2022/11/1
期刊
CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders)
卷号
21
期号
9
页码范围
854-868
出版商
Bentham Science Publishers
简介
Background
Fetal Alcohol Spectrum Disorders (FASD) are the manifestation of the damage caused by alcohol consumption during pregnancy. Children with Fetal Alcohol Syndrome (FAS), the extreme FASD manifestation, show both facial dysmorphology and mental retardation. Alcohol consumed during gestational age prejudices brain development by reducing, among others, the synthesis and release of neurotrophic factors and neuroinflammatory markers. Alcohol drinking also induces oxidative stress.
Hypothesis/Objective
The present study aimed to investigate the potential association between neurotrophins, neuroinflammation, and oxidative stress in 12 prepubertal male and female FASD children diagnosed as FAS or partial FAS (pFAS).
Methods
Accordingly, we analyzed, in the serum, the level of BDNF and NGF and the oxidative stress, as Free Oxygen Radicals Test (FORT) and Free Oxygen Radicals …
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M Fiore, C Petrella, G Coriale, P Rosso, E Fico, M Ralli… - CNS & Neurological Disorders-Drug Targets (Formerly …, 2022