作者
Vibha Puri, David Brancazio, Eranda Harinath, Alexander R Martinez, Parind M Desai, Keith D Jensen, Jung-Hoon Chun, Richard D Braatz, Allan S Myerson, Bernhardt L Trout
发表日期
2018/1/15
期刊
International journal of pharmaceutics
卷号
535
期号
1-2
页码范围
106-112
出版商
Elsevier
简介
We demonstrate the coating of tablets using an injection molding (IM) process that has advantage of being solvent free and can provide precision coat features. The selected core tablets comprising 10% w/w griseofulvin were prepared by an integrated hot melt extrusion-injection molding (HME-IM) process. Coating trials were conducted on a vertical injection mold machine. Polyethylene glycol and polyethylene oxide based hot melt extruded coat compositions were used. Tablet coating process feasibility was successfully demonstrated using different coating mold designs (with both overlapping and non-overlapping coatings at the weld) and coat thicknesses of 150 and 300 μm. The resultant coated tablets had acceptable appearance, seal at the weld, and immediate drug release profile (with an acceptable lag time). Since IM is a continuous process, this study opens opportunities to develop HME-IM continuous …
引用总数
201820192020202120222023223213
学术搜索中的文章
V Puri, D Brancazio, E Harinath, AR Martinez… - International journal of pharmaceutics, 2018