作者
David Margel, David R Urbach, Lorraine L Lipscombe, Chaim M Bell, Girish Kulkarni, Peter C Austin, Neil Fleshner
发表日期
2013/9/1
期刊
Journal of Clinical Oncology
卷号
31
期号
25
页码范围
3069-3075
出版商
American Society of Clinical Oncology
简介
Purpose
To evaluate the association between cumulative duration of metformin use after prostate cancer (PC) diagnosis and all-cause and PC-specific mortality among patients with diabetes.
Patients and Methods
We used a population-based retrospective cohort design. Data were obtained from several Ontario health care administrative databases. Within a cohort of men older than age 66 years with incident diabetes who subsequently developed PC, we examined the effect of duration of antidiabetic medication exposure after PC diagnosis on all-cause and PC-specific mortality. Crude and adjusted hazard ratios (HRs) were calculated by using a time-varying Cox proportional hazard model to estimate effects.
Results
The cohort consisted of 3,837 patients. Median age at diagnosis of PC was 75 years (interquartile range [IQR], 72 to 79 years). During a median follow-up of 4.64 years (IQR, 2.7 to 7.1 years), 1,343 …
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