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57 ABSTRACT A System and method non-invasive biomedical optical imag ing and spectroscopy with low-level light is described. The technique consists of a modulated light Source (120) coupled to tissue (100) of a patient to introduce excitation light. Fluorescent light emitted in response to the excitation light is detected with sensor (148). The AC intensity and phase of the excitation and detected fluorescent light is provided to a processor (160) operatively coupled to sensor (148). Pro cessor (160) employs the measured re-emission kinetics of excitation and fluorescent light to" map'the Spatial variation of one or more fluorescence characteristics of the tissue (100). The fluorescence characteristic may be provided by exogenous contract agents, endogenous fluorophores, or both. The variation is determined by Solving frequency domain diffusion equations at a number of designated points in the tissue as part of a …