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Bioelectrical impedance spectroscopy (BIS) devices are being used to determine ultrafiltration requirements to achieve target weight for haemodialysis (HD) patients. Pre-dialysis measurements are more convenient for both patients and staff. We wished to compare the changes in pre-and post-dialysis hydration measured by BIS with actual weight loss. We compared paired BIS measurements made pre and post HD using a BIS device based on a 3-compartmental model, designed to provide information on extracellular water (ECW) excess. BIS was measured in 49 HD patients, 35 male (71.4%) with mean age 67.6±14.2. Weight fell significantly from 69.2±17.8 to 67.6±17.4 kg, and BIS over hydration (OH) from 4.5±3.3. 4 to 3.4±2.9 litres, and ECW from 16.8±4.8 to 15.5±4.4 litres, but there was no change in the amount of intracellular water. Weight loss correlated positively with the …