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Bone is a dynamic organ that maintains its proper architecture and function by undergoing continuous cycles of modelling and remodelling during normal host physiology. Any dysregulation in the bone remodelling process leads to the development of bone-related disorders including osteoporosis. Osteoporosis is considered as one of the most commonly occurring but often neglected bone diseases leading to enhanced fragility and morbidity in large number of populations. Presently, available drugs (strontium, bisphosphonates, oestrogen replacement therapy, etc.) that are being used as a therapy for treating osteoporosis come with higher side effects and complications later in life. Thus, newer therapies are need of the hour for better management and treatment of osteoporosis-related bone loss. Various studies indicate that immune responses (both innate and adaptive) play crucial role in the development and …