作者
Changchun He, Yanchi Chen, Taorong Jian, Heng Chen, Xiaonan Guo, Jia Wang, Lijie Wu, Huafu Chen, Xujun Duan
发表日期
2018/11
期刊
Autism Research
卷号
11
期号
11
页码范围
1479-1493
出版商
John Wiley & Sons, Inc.
简介
Accumulating neuroimaging evidence suggests that abnormal functional connectivity of the default mode network (DMN) contributes to the social‐cognitive deficits of autism spectrum disorder (ASD). Although most previous studies relied on conventional functional connectivity methods, which assume that connectivity patterns remain constant over time, understanding the temporal dynamics of functional connectivity during rest may provide new insights into the dysfunction of the DMN in ASD. In this work, dynamic functional connectivity analysis based on sliding time window correlation was applied to the resting‐state functional magnetic resonance imaging data of 28 young children with ASD (age range: 3–7 years) and 29 matched typically developing controls (TD group). In addition, k‐means cluster analysis was performed to identify distinct temporal states based on the spatial similarity of each functional …
引用总数
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