作者
Patricia E Hewitt, Samreen Ijaz, Su R Brailsford, Rachel Brett, Steven Dicks, Becky Haywood, Iain TR Kennedy, Alan Kitchen, Poorvi Patel, John Poh, Katherine Russell, Kate I Tettmar, Joanne Tossell, Ines Ushiro-Lumb, Richard S Tedder
发表日期
2014/11/15
期刊
The Lancet
卷号
384
期号
9956
页码范围
1766-1773
出版商
Elsevier
简介
Background
The prevalence of hepatitis E virus (HEV) genotype 3 infections in the English population (including blood donors) is unknown, but is probably widespread, and the virus has been detected in pooled plasma products. HEV-infected donors have been retrospectively identified through investigation of reported cases of possible transfusion-transmitted hepatitis E. The frequency of HEV transmission by transfusion and its outcome remains unknown. We report the prevalence of HEV RNA in blood donations, the transmission of the virus through a range of blood components, and describe the resulting morbidity in the recipients.
Methods
From Oct 8, 2012, to Sept 30, 2013, 225 000 blood donations that were collected in southeast England were screened retrospectively for HEV RNA. Donations containing HEV were characterised by use of serology and genomic phylogeny. Recipients, who received any blood …
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PE Hewitt, S Ijaz, SR Brailsford, R Brett, S Dicks… - The Lancet, 2014