作者
Catherine Cohet, François Haguinet, Gaël Dos Santos, Dave Webb, John Logie, Germano LC Ferreira, Dominique Rosillon, Vivek Shinde
发表日期
2016/1/1
期刊
BMJ open
卷号
6
期号
1
页码范围
e009264
出版商
British Medical Journal Publishing Group
简介
Objective
To assess the risk of solid organ transplant (SOT) rejection after vaccination with the adjuvanted (AS03) A/H1N1 2009 pandemic influenza vaccine Pandemrix.
Design
Self-controlled case series (SCCS) in the UK Clinical Practice Research Datalink (CPRD) and its linked component of the Hospital Episodes Statistics (HES) inpatient database. Analyses were conducted using the SCCS method for censored, perturbed or curtailed post-event exposure.
Participants
Of the 184 transplant recipients having experienced at least one SOT rejection (liver, kidney, lung, heart or pancreas) during the study period from 1 October 2009 to 31 October 2010, 91 participants were included in the main analysis, of which 71 had been exposed to Pandemrix.
Main outcome measures
Occurrence of SOT rejection during risk (30 and 60 days after any Pandemrix dose) and control periods. Covariates in the CPRD included time …
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C Cohet, F Haguinet, G Dos Santos, D Webb, J Logie… - BMJ open, 2016
