作者
Ashish Bhargava, Hemang Patel, Elisa Akagi, Mamta Sharma, Claudia V Santos, Wei Zhao, Natali Salaytah, Goutham Kondapi, Nilamben Mangukia, Meredith M Coyle, Kathleen M Riederer, Leonard B Johnson, Louis Saravolatz
发表日期
2022/12/1
期刊
Open Forum Infectious Diseases
卷号
9
期号
Supplement_2
页码范围
ofac492. 883
出版商
Oxford University Press
简介
Background
The ongoing state of the COVID-19 pandemic necessitates the characterization of the biological basis of disease severity. We aimed to correlate the clinical severity of illness upon hospitalization with inflammatory sero-biomarker levels.
Methods
A single-center prospective cohort study was conducted at a 776-bed tertiary care urban academic medical center in Detroit, Michigan. Adults with confirmed reverse-transcriptase-polymerase-chain-reaction assay for COVID-19 were recruited in equal numbers into four disease severity categories, as defined by the WHO, upon hospital admission from January 8th, 2021 to September 1st, 2021. Electronic medical charts were reviewed. In addition to clinical markers, cytokines and chemokines were assessed to gain detailed understanding of COVID-19 pathology.
Results
We included 200 patients with …
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A Bhargava, H Patel, E Akagi, M Sharma, CV Santos… - Open Forum Infectious Diseases, 2022