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The current study aimed to provide incite in to the prescriptive patterns of antihypertensive drugs in a south Indian super-specialty hospital. This prospective study was conducted in multi specialty hospital in southern Indian state of Andhra Pradesh from June 2012 to September 2012. Data was obtained from a prospective series of 205 patients of either sex by scrutinizing the outpatient cards and laboratory reports of inpatients attending the hospital. The data collected were analyzed for prescribing patterns of antihypertensive drugs and demographic profiles of the patients suffering from hypertension. The results were analyzed and tabulated statistically by student’st test. P value< 0.05* is considered. The present study revealed that calcium channel blockers were the drugs of choice for hypertensive patients as a single drug therapy and overall utilization. Utilization of diuretics in the present study was 5.1% as mono therapy which is lesser even though they are available at lower cost. The study showed that a higher percentage of patients (56.09%) were found to be on dual therapy and among them 73 (63.4%) were found to be treated with fixed dose combination i. e ARB+ Diuretic followed by beta blockers+ CCBs and the reduction of SBP and DBP was found to be significant with these combinations and the pattern is according to JNC guidelines. The study revealed that the prescription of antihypertensive medication is according to JNC guidelines, except monotherapy of diuretics.