作者
Marisa DiMarzio, Tanweer Rashid, Ileana Hancu, Eric Fiveland, Julia Prusik, Michael Gillogly, Radhika Madhavan, Suresh Joel, Jennifer Durphy, Eric Molho, Era Hanspal, Damian Shin, Julie G Pilitsis
发表日期
2019/12/1
期刊
Neurosurgery
卷号
85
期号
6
页码范围
E1043-E1049
出版商
LWW
简介
BACKGROUND
Chronic pain occurs in 83% of Parkinson disease (PD) patients and deep brain stimulation (DBS) has shown to result in pain relief in a subset of patients, though the mechanism is unclear.
OBJECTIVE
To compare functional magnetic resonance imaging (MRI) data in PD patients with chronic pain without DBS, those whose pain was relieved (PR) with DBS and those whose pain was not relieved (PNR) with DBS.
METHODS
Functional MRI (fMRI) with blood oxygen level-dependent activation data was obtained in 15 patients in control, PR, and PNR patients. fMRI was obtained in the presence and absence of a mechanical stimuli with DBS ON and DBS OFF. Voxel-wise analysis using pain OFF data was used to determine which regions were altered during pain ON periods.
RESULTS
At the time of MRI, pain was scored a 5.4±1.2 out of 10 in the control, 4.25±1.18 in PNR, and 0.8±0.67 in PR cohorts …
学术搜索中的文章
M DiMarzio, T Rashid, I Hancu, E Fiveland, J Prusik… - Neurosurgery, 2019