作者
Joris Deelen, Marian Beekman, Hae‐Won Uh, Quinta Helmer, Maris Kuningas, Lene Christiansen, Dennis Kremer, Ruud van der Breggen, H Eka D Suchiman, Nico Lakenberg, Erik B van den Akker, Willemijn M Passtoors, Henning Tiemeier, Diana van Heemst, Anton J de Craen, Fernando Rivadeneira, Eco J de Geus, Markus Perola, Frans J van der Ouderaa, David A Gunn, Dorret I Boomsma, André G Uitterlinden, Kaare Christensen, Cornelia M van Duijn, Bastiaan T Heijmans, Jeanine J Houwing‐Duistermaat, Rudi GJ Westendorp, P Eline Slagboom
发表日期
2011/8
期刊
Aging cell
卷号
10
期号
4
页码范围
686-698
出版商
Blackwell Publishing Ltd
简介
By studying the loci that contribute to human longevity, we aim to identify mechanisms that contribute to healthy aging. To identify such loci, we performed a genome‐wide association study (GWAS) comparing 403 unrelated nonagenarians from long‐living families included in the Leiden Longevity Study (LLS) and 1670 younger population controls. The strongest candidate SNPs from this GWAS have been analyzed in a meta‐analysis of nonagenarian cases from the Rotterdam Study, Leiden 85‐plus study, and Danish 1905 cohort. Only one of the 62 prioritized SNPs from the GWAS analysis (P < 1 × 10−4) showed genome‐wide significance with survival into old age in the meta‐analysis of 4149 nonagenarian cases and 7582 younger controls [OR = 0.71 (95% CI 0.65–0.77), P = 3.39 × 10−17]. This SNP, rs2075650, is located in TOMM40 at chromosome 19q13.32 close to the apolipoprotein E (APOE …
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J Deelen, M Beekman, HW Uh, Q Helmer, M Kuningas… - Aging cell, 2011