作者
Joris Deelen, Marian Beekman, Hae-Won Uh, Linda Broer, Kristin L Ayers, Qihua Tan, Yoichiro Kamatani, Anna M Bennet, Riin Tamm, Stella Trompet, Daníel F Guðbjartsson, Friederike Flachsbart, Giuseppina Rose, Alexander Viktorin, Krista Fischer, Marianne Nygaard, Heather J Cordell, Paolina Crocco, Erik B Van den Akker, Stefan Böhringer, Quinta Helmer, Christopher P Nelson, Gary I Saunders, Maris Alver, Karen Andersen-Ranberg, Marie E Breen, Ruud van Der Breggen, Amke Caliebe, Miriam Capri, Elisa Cevenini, Joanna C Collerton, Serena Dato, Karen Davies, Ian Ford, Jutta Gampe, Paolo Garagnani, Eco JC de Geus, Jennifer Harrow, Diana Van Heemst, Bastiaan T Heijmans, Femke-Anouska Heinsen, Jouke-Jan Hottenga, Albert Hofman, Bernard Jeune, Palmi V Jonsson, Mark Lathrop, Doris Lechner, Carmen Martin-Ruiz, Susan E Mcnerlan, Evelin Mihailov, Alberto Montesanto, Simon P Mooijaart, Anne Murphy, Ellen A Nohr, Lavinia Paternoster, Iris Postmus, Fernando Rivadeneira, Owen A Ross, Stefano Salvioli, Naveed Sattar, Stefan Schreiber, Hreinn Stefánsson, David J Stott, Henning Tiemeier, André G Uitterlinden, Rudi GJ Westendorp, Gonneke Willemsen, Nilesh J Samani, Pilar Galan, Thorkild IA Sørensen, Dorret I Boomsma, J Wouter Jukema, Irene Maeve Rea, Giuseppe Passarino, Anton JM de Craen, Kaare Christensen, Almut Nebel, Kári Stefánsson, Andres Metspalu, Patrik Magnusson, Hélène Blanché, Lene Christiansen, Thomas BL Kirkwood, Cornelia M Van Duijn, Claudio Franceschi, Jeanine J Houwing-Duistermaat, P Eline Slagboom
发表日期
2014/8/15
期刊
Human molecular genetics
卷号
23
期号
16
页码范围
4420-4432
出版商
Oxford University Press
简介
The genetic contribution to the variation in human lifespan is ∼25%. Despite the large number of identified disease-susceptibility loci, it is not known which loci influence population mortality. We performed a genome-wide association meta-analysis of 7729 long-lived individuals of European descent (≥85 years) and 16 121 younger controls (<65 years) followed by replication in an additional set of 13 060 long-lived individuals and 61 156 controls. In addition, we performed a subset analysis in cases aged ≥90 years. We observed genome-wide significant association with longevity, as reflected by survival to ages beyond 90 years, at a novel locus, rs2149954, on chromosome 5q33.3 (OR = 1.10, P = 1.74 × 10−8). We also confirmed association of rs4420638 on chromosome 19q13.32 (OR = 0.72, P = 3.40 × 10−36), representing the TOMM40/APOE/APOC1 locus. In a prospective meta-analysis (n = 34 103 …
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J Deelen, M Beekman, HW Uh, L Broer, KL Ayers… - Human molecular genetics, 2014