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Pilot investigations have suggested that a novel, long‐acting, injectable i.m. formulation of omeprazole (LA‐OMEP) can induce acid suppression for up to 7 days following a single injection.

To investigate the pharmacodynamics and assess the clinical efficacy of the LA‐OMEP formulation.

Part A comprised a pharmacodynamic study. Part B consisted of a pilot clinical trial.

Part A enrolled six adult Thoroughbred horses with percutaneous gastrotomy tubes. Intragastric pH was measured for continuous 23‐h periods (08.00–07.00 h) for eight consecutive days (days 0–7). A single 2.0‐g dose of a 100 mg/mL LA‐OMEP formulation was administered at 08.00 h on day 1. In Part B, 26 horses with squamous or glandular gastric disease were enrolled based on routine gastroscopic evaluation. Once enrolled, horses received 2.0 g of the 100 mg/mL LA‐OMEP formulation by i …