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Deep learning is an obvious method for the detection of disease, analyzing medical images and many researchers have looked into it. However, the performance of deep learning algorithms is frequently influenced by hyperparameter selection, the question of which combination of hyperparameters are best emerges. To address this challenge, we proposed a novel algorithm for Adaptive Hyperparameter Tuning (AHT) that automates the selection of optimal hyperparameters for Convolutional Neural Network (CNN) training. All of the optimal hyperparameters for the CNN models were instantaneously selected and allocated using a novel proposed algorithm Adaptive Hyperparameter Tuning (AHT). Using AHT, enables CNN models to be highly autonomous to choose optimal hyperparameters for classifying medical images into various classifications. The CNN model (Deep-Hist) categorizes medical images into basic classes: malignant and benign, with an accuracy of 95.71%. The most dominant CNN models such as ResNet, DenseNet, and MobileNetV2 are all compared to the already proposed CNN model (Deep-Hist). Plausible classification results were obtained using large, publicly available clinical datasets such as BreakHis, BraTS, NIH-Xray and COVID-19 X-ray. Medical practitioners and clinicians can utilize the CNN model to corroborate their first malignant and benign classification assessment. The recommended Adaptive high F1 score and precision, as well as its excellent generalization and accuracy, imply that it might be used to build a pathologist’s aid tool.