作者
Antonis C Antoniou, AP Cunningham, J Peto, DG Evans, F Lalloo, SA Narod, HA Risch, JE Eyfjord, JL Hopper, MC Southey, Håkan Olsson, O Johannsson, A Borg, B Passini, P Radice, S Manoukian, DM Eccles, N Tang, E Olah, H Anton-Culver, E Warner, J Lubinski, J Gronwald, B Gorski, L Tryggvadottir, K Syrjakoski, OP Kallioniemi, H Eerola, H Nevanlinna, PDP Pharoah, DF Easton
发表日期
2008/4
期刊
British journal of cancer
卷号
98
期号
8
页码范围
1457-1466
出版商
Nature Publishing Group
简介
Multiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously developed a model (BOADICEA) under which susceptibility to breast cancer is explained by mutations in BRCA1 and BRCA2, as well as by the joint multiplicative effects of many genes (polygenic component). We have now updated BOADICEA using additional family data from two UK population-based studies of breast cancer and family data from BRCA1 and BRCA2 carriers identified by 22 population-based studies of breast or ovarian cancer. The combined data set includes 2785 families (301 BRCA1 positive and 236 BRCA2 positive). Incidences were smoothed using locally weighted regression techniques to avoid large variations between adjacent intervals. A birth cohort effect on the cancer risks was implemented, whereby each individual was assumed to develop cancer according to calendar period-specific …
引用总数
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AC Antoniou, AP Cunningham, J Peto, DG Evans… - British journal of cancer, 2008