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The predominant catechins [epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin (EC), epicatechin gallate (ECG)] in green tea extract (GTE) vary in bioactivity. Our objective was to develop a physiologically relevant mathematical model of catechin metabolism and assess their fractional catabolic rates relative to their structural attributes, which may influence their bioactivities.

Pharmacokinetic data were collected from healthy adults (n = 18; 27 ± 7 y; 22 ± 2 kg/m²) after oral intake of 0.5 g GTE (EGCG: 290 mg, EGC: 87 mg, EC: 39 mg, ECG: 28 mg) delivered in 3 gelatin-based confections. Participants maintained a low-polyphenol diet for 3 d prior to the trial. Concentrations of deconjugated catechins were measured by LC-MS in plasma and urine collected at timed intervals over 12 and 24 h, respectively. A multi-compartment model of catechin metabolism was developed using the …