作者
María Esperanza Rodriguez-Ruiz, Jose Luis Perez-Gracia, Inmaculada Rodriguez, Carlos Alfaro, Carmen Oñate, Guiomar Perez, Ignacio Gil-Bazo, Amparo Benito, Susana Inoges, A López-Diaz De Cerio, Mariano Ponz-Sarvise, Leyre Resano, Pedro Berraondo, B Barbés, Salvador Martin-Algarra, Alfonso Gúrpide, MF Sanmamed, C De Andrea, AM Salazar, Ignacio Melero
发表日期
2018/5/1
期刊
Annals of Oncology
卷号
29
期号
5
页码范围
1312-1319
出版商
Elsevier
简介
Background
Combination immunotherapy has the potential to achieve additive or synergistic effects. Combined local injections of dsRNA analogues (mimicking viral RNA) and repeated vaccinations with tumor-lysate loaded dendritic cells shows efficacy against colon cancer mouse models. In the context of immunotherapy, radiotherapy can exert beneficial abscopal effects.
Patients and methods
In this two-cohort pilot phase I study, 15 advanced cancer patients received two 4-week cycles of four intradermal daily doses of monocyte-derived dendritic cells preloaded with autologous tumor lysate and matured for 24 h with poly-ICLC (Hiltonol), TNF-α and IFN-α. On days +8 and +10 of each cycle, patients received intratumoral image-guided 0.25 mg injections of the dsRNA-analogue Hiltonol. Cyclophosphamide 600 mg/m2 was administered 1 week before. Six patients received stereotactic ablative radiotherapy (SABR …
学术搜索中的文章
ME Rodriguez-Ruiz, JL Perez-Gracia, I Rodriguez… - Annals of Oncology, 2018