作者
Anastasios Maniakas, Ramona Dadu, Naifa Busaidy, Jennifer Wang, Renata Ferrarotto, Charles Lu, Michelle Williams, G Gunn, Marie-Claude Hofmann, Gilbert Cote, Jared Sperling, Neil Gross, Erich Sturgis, Ryan Goepfert, Stephen Lai, Maria Cabanillas, Mark Zafereo
发表日期
2020/9
期刊
Jama Oncology
卷号
6
期号
9
页码范围
1397-1404
简介
Importance
Anaplastic thyroid carcinoma (ATC) historically has a 4-month median overall survival (OS) from time of diagnosis, with disease-specific mortality approaching 100%. The association between recent major advancements in treatment and OS has yet to be evaluated.
Objective
To evaluate rates of OS in patients with ATC over the last 2 decades.
Design, Setting, and Participants
Retrospective cohort study in a single tertiary care institution. Patients with histopathological confirmation of ATC from January 2000 to October 2019 were included and divided into 3 groups according to date of presentation: 2000-2013, 2014-2016, and 2017-2019.
Main Outcomes and Measures
Overall survival compared among different treatment eras and differing therapies, including targeted therapy, immunotherapy, and surgery.
Results
Of 479 patients (246 men [51%]; median age, 65.0 [range, 21.1-92.6] years) with ATC …
学术搜索中的文章
A Maniakas, R Dadu, NL Busaidy, JR Wang… - JAMA oncology, 2020